Researchers have shown that a beneficial substance produced in the gut — formed after consuming foods like pomegranate (and some other fruits) — can help strengthen and rejuvenate the immune system in middle age. This compound provides partial protection against cellular damage, inflammation, and some chronic diseases, including cancer.
Urolithin A” (UA) is a natural compound produced by gut bacteria in response to the intake of ellagitannins from foods such as pomegranate, almonds, and certain types of berries.
Scientific studies show that UA can enhance the immune system safely and effectively. It increases the number of CD8+ T cells (cytotoxic T cells that play a key role in the body’s defense).
These cells also produced higher levels of PGC-1α, a protein that plays an important role in the formation and regeneration of mitochondria — a process essential for cellular energy production and overall ce
People who consumed UA showed lower oxidative stress and improvements in certain inflammatory markers.
In summary, UA activates a process called mitophagy, through which cells recycle old mitochondria and renew cellular energy. This increases the number of young, fresh T cells, thereby improving the immune system’s ability to eliminate pathogens.
Author: Bronwyn Thompson November 16, 2025
